The Synology DiskStation DS1621xs+ is a 6-bay NAS designed for enterprise use. It comes with 8GB DDR4 ECC of RAM and can be upgraded to 32GB DDR4 ECC. Powered by the Intel Xeon Quad-Core processor, it offers reliable network-attached storage for file sharing, backups, and media streaming.
This guide covers complete RAM and storage compatibility for the Synology DiskStation DS1621xs+, including upgrade options, maximum supported configurations, and recommended drives.
Specifications Overview
| Specification | Details |
|---|---|
| NAS Model | Synology DiskStation DS1621xs+ |
| Brand | Synology |
| Drive Bays | 6 bays |
| Processor | Intel Xeon Quad-Core |
| Default RAM | 8GB DDR4 ECC |
| Maximum RAM | 32GB DDR4 ECC |
| RAM Type | DDR4 ECC |
| RAM Slots | 2 |
| RAM Upgradeable | Yes |
| M.2 Slots | 2 (2280 NVMe) |
| Ethernet | 4x 1GbE + 1x 10GbE |
| USB Ports | 3x USB 3.2 Gen 1 + 2x eSATA |
| Use Case | Enterprise |
| Price Tier | High-End |
Memory (RAM) Compatibility
The Synology DiskStation DS1621xs+ ships with 8GB DDR4 ECC and supports a maximum of 32GB DDR4 ECC across 2 slots. Upgrading your NAS RAM can significantly improve performance for virtual machines, Docker containers, and simultaneous user access.
Recommended RAM Upgrades
| Module | Capacity | Price |
|---|---|---|
| Crucial ECC SODIMM | 4GB | Check Price |
| Crucial ECC SODIMM | 8GB | Check Price |
| Crucial ECC SODIMM | 16GB | Check Price |
Storage Compatibility

The Synology DiskStation DS1621xs+ has 6 drive bays supporting 3.5″ SATA HDDs and 2.5″ SATA SSDs.
It also includes 2 M.2 slots (2280 NVMe) for NVMe SSD caching, which can dramatically improve random read/write performance.
Recommended NAS Hard Drives
| Drive | Capacity | Price |
|---|---|---|
| Seagate IronWolf | 4TB | Check Price |
| Seagate IronWolf | 8TB | Check Price |
| WD Red Plus | 4TB | Check Price |
| WD Red Plus | 8TB | Check Price |
Recommended NVMe Cache Drives
| Drive | Capacity | Price |
|---|---|---|
| WD Red SN700 | 500GB NVMe | Check Price |
| Seagate IronWolf 525 | 500GB NVMe | Check Price |
Network Connectivity
The Synology DiskStation DS1621xs+ features 4x 1GbE + 1x 10GbE Ethernet and 3x USB 3.2 Gen 1 + 2x eSATA connectivity.
With high-speed Ethernet, this NAS can fully utilise fast NVMe cache drives and multiple concurrent connections.
Related Guides
Frequently Asked Questions
What is the maximum RAM for the Synology DiskStation DS1621xs+?
The Synology DiskStation DS1621xs+ supports a maximum of 32GB DDR4 ECC. It ships with 8GB DDR4 ECC by default.
How many drive bays does the Synology DiskStation DS1621xs+ have?
The Synology DiskStation DS1621xs+ has 6 drive bays supporting 3.5″ SATA HDDs and 2.5″ SATA SSDs. It also has 2 M.2 slots for NVMe SSD caching.
Can I upgrade the RAM in the Synology DiskStation DS1621xs+?
Yes, the RAM is user-upgradeable.
What hard drives work with the Synology DiskStation DS1621xs+?
The Synology DiskStation DS1621xs+ works with standard 3.5″ SATA HDDs. We recommend NAS-rated drives like the Seagate IronWolf or WD Red Plus.
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Prices from PCHub.UK via ComputersDeal. As an affiliate, we may earn from qualifying purchases. Prices updated 2026-04-10 13:15:58.

