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The Synology DiskStation DS1621+ is a 6-bay NAS designed for small business use. It comes with 4GB DDR4 ECC of RAM and can be upgraded to 32GB DDR4 ECC. Powered by the AMD Ryzen V1500B processor, it offers reliable network-attached storage for file sharing, backups, and media streaming.
This guide covers complete RAM and storage compatibility for the Synology DiskStation DS1621+, including upgrade options, maximum supported configurations, and recommended drives.
Specifications Overview
| Specification | Details |
|---|---|
| NAS Model | Synology DiskStation DS1621+ |
| Brand | Synology |
| Drive Bays | 6 bays |
| Processor | AMD Ryzen V1500B |
| Default RAM | 4GB DDR4 ECC |
| Maximum RAM | 32GB DDR4 ECC |
| RAM Type | DDR4 ECC |
| RAM Slots | 2 |
| RAM Upgradeable | Yes |
| M.2 Slots | 2 (2280 NVMe) |
| Ethernet | 4x 1GbE + 1x 10GbE upgrade slot |
| USB Ports | 3x USB 3.2 Gen 1 + 2x eSATA |
| Use Case | Small Business |
| Price Tier | Mid-Range |
Memory (RAM) Compatibility
The Synology DiskStation DS1621+ ships with 4GB DDR4 ECC and supports a maximum of 32GB DDR4 ECC across 2 slots. Upgrading your NAS RAM can significantly improve performance for virtual machines, Docker containers, and simultaneous user access.
Recommended RAM Upgrades
| Module | Capacity | Price* |
|---|---|---|
| Crucial ECC SODIMM | 4GB | Check Price |
| Crucial ECC SODIMM | 8GB | Check Price |
| Crucial ECC SODIMM | 16GB | Check Price |
Storage Compatibility
The Synology DiskStation DS1621+ has 6 drive bays supporting 3.5″ SATA HDDs and 2.5″ SATA SSDs.
It also includes 2 M.2 slots (2280 NVMe) for NVMe SSD caching, which can dramatically improve random read/write performance.
Recommended NAS Hard Drives
| Drive | Capacity | Price* |
|---|---|---|
| Seagate IronWolf | 4TB | Check Price |
| Seagate IronWolf | 8TB | Check Price |
| WD Red Plus | 4TB | Check Price |
| WD Red Plus | 8TB | Check Price |
Recommended NVMe Cache Drives
| Drive | Capacity | Price* |
|---|---|---|
| WD Red SN700 | 500GB NVMe | Check Price |
| Seagate IronWolf 525 | 500GB NVMe | Check Price |
Network Connectivity
The Synology DiskStation DS1621+ features 4x 1GbE + 1x 10GbE upgrade slot Ethernet and 3x USB 3.2 Gen 1 + 2x eSATA connectivity.
With high-speed Ethernet, this NAS can fully utilise fast NVMe cache drives and multiple concurrent connections.
Related Guides
Frequently Asked Questions
What is the maximum RAM for the Synology DiskStation DS1621+?
The Synology DiskStation DS1621+ supports a maximum of 32GB DDR4 ECC. It ships with 4GB DDR4 ECC by default.
How many drive bays does the Synology DiskStation DS1621+ have?
The Synology DiskStation DS1621+ has 6 drive bays supporting 3.5″ SATA HDDs and 2.5″ SATA SSDs. It also has 2 M.2 slots for NVMe SSD caching.
Can I upgrade the RAM in the Synology DiskStation DS1621+?
Yes, the RAM is user-upgradeable.
What hard drives work with the Synology DiskStation DS1621+?
The Synology DiskStation DS1621+ works with standard 3.5″ SATA HDDs. We recommend NAS-rated drives like the Seagate IronWolf or WD Red Plus.
Upgrades that fit the Synology DiskStation DS1621+
What fits: Memory: DDR4 SO-DIMM, 2 user slots, up to 32GB · Storage: 2x M.2 2280; 2.5in SATA drive supported · Charger: internal PSU, AC mains inlet (100-240V)
Spec source: global.download.synology.com (checked 26 Sep 2026).
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2.5in SATA SSDs for the drive bay
*Indicative UK street prices, shown for guidance only. These are not live Amazon prices and change frequently — check the current price on Amazon before buying.
